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Quantum Flex Cell Expansion System FINIA Fill and Finish System Welders & Sealers Reliable, sterile connections using cost-effective tubing welders and sealers
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Quantum Flex in use

Quantum Flex Cell Expansion System

Accelerate your commercialization journey with an automated cell culture environment

Simplified cell expansion, one automated platform

You know that successful cell expansion is critical for taking a cell or gene therapy from scientific breakthrough to process development to commercialized patient treatment. Now you can elevate this essential process with the Quantum Flex™ Cell Expansion System, an automated, functionally closed system that simplifies, de-risks, and accelerates your journey — all within a single platform.

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A cell expansion solution with low seeding requirements

The Quantum Flex system from Terumo Blood and Cell Technologies is a holistic, connected solution designed to meet your multiple cell culture bioreactor needs. Quantum Flex is suitable for a variety of cell types and applications and is scalable, reducing the need for multiple platforms.

This automated cell culture solution has minimal seeding requirements. And, using hollow-fiber perfusion technology, it can produce billions of suspension cells and hundreds of millions of adherent cells with a harvest volume of less than 1 L, simplifying downstream processing.

Integrated software assists with monitoring and process control and helps facilitate Good Manufacturing Practices (GMP) compliance.

Combined, these advantages — highlighted in the illustration — can also help reduce labor, costs, and open events.

Six key benefits of Quantum Flex:

  • Scalability
  • Connectivity
  • Minimal seeding requirements
  • Concentrated harvest volume
  • cGMP compliance
  • Adaptability

Flexible cell expansion for a wide variety of therapies

With flexibility and adaptability built into its innovative design, Quantum Flex fits into your process, regardless of what cell type you are working with or what type of therapy you are manufacturing. It provides a robust environment for both suspension cell culture (including T cell culture) and adherent cell culture (including mesenchymal stem cell culture). It accommodates a variety of starting material requirements and harvest needs, and it tolerates a range of common media and reagents.

 

Cell types and applications successfully performed on Quantum Flex 

Suspension Cell Expansion
Adherent Cell Expansion 
Applications 

T cells

Human pluripotent stem cells (ESCs, iPSCs)

Viral vector production using adherent and suspension HEK293 cells

Tregs

Mesenchymal stem cells (MSCs)

Exosome production 

Tumor-infiltrating lymphocytes (TILs)

Fibroblasts

--

CAR-T cells

Endothelial cells

--

CD34+ cells

Neural stem cells (NSCs)

--

*Performance varies by user and is dependent on customer processes and materials.

See examples of the Quantum Flex autologous CAR-T workflow and MSC seed train processes.

View our illustrated infographic and begin charting your own path to scalable cell expansion.

Download the infographic

Cell manufacturing that scales as your therapy needs evolve and progress

As an automated, perfusion-based cell expansion system, Quantum Flex scales to fit your needs and adapts to your process as your therapy moves from process development to commercial production. Two sizes of hollow-fiber bioreactor allow you to transition between batch sizes on the same platform — so you can scale up or down as needed for each stage of your process, potentially saving time and money.



A group of Quantum Flex devices in use.

Quick view: See how the Quantum Flex cell expansion platform scales with your process, from early automation to commercialization.

  A steady transition can be vital to your therapy development.

Download the infographic

Help ensure uptime and more with our service packages

Learn about our Veda™ Check solution — installation qualification and operation qualification (IQ/OQ), preventive maintenance, and other service offerings designed to boost operational confidence.

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Streamlined path to GMP compliance

Quantum Flex and its integrated Cell Processing Application (CPA™) software can help you reduce the time, risk, and cost of compliance and data management

  • Facilitation of cGMP compliance, including with FDA 21 CFR Part 211
  • Maintain data integrity and facilitate compliance with FDA 21 CFR Part 11 and EU GMP Annex 11
  • Provides a fully non-DEHP fluid path
  • Barcode scanning to track material use and enforce rules
  • User roles and authentication
  • Comprehensive run reporting

Your partners in cell expansion and therapy development

Bringing a new cell or gene therapy to market is a long, complex journey. Quantum Flex can help you accelerate and elevate the process with an automated cell culture environment where cells thrive.

The Terumo Blood and Cell Technologies team is here for you at every step, from product demonstrations to installation, installation qualification/operational qualification (IQ/OQ), ongoing service, and consultation, all the way to commercialization.

Featured resources

For operator's manuals and Instructions for Use, visit our eIFU website: Terumo.eifu.com. For more information, visit Help.TerumoBCT.com.

Let’s discuss how Quantum Flex can work in your facility and help your cells thrive

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