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person scanning plasma bag on mirasol device

Mirasol Pathogen Reduction Technology

Reduce the pathogen load in donated blood and inactivate residual white blood cells

A proactive approach to improved blood safety

No matter where you are located, increased travel, climate change, evolving pathogens, emerging pandemics, and the need to advance healthcare practices have put global blood safety at the forefront of industry focus.

With all this change, it’s time to take a proactive approach to protecting patients from the potential dangers of donated blood.

The Mirasol™ Pathogen Reduction Technology (PRT) system can help you do that by reducing the pathogen load of a broad range of disease-causing viruses, bacteria, and parasites.

The system also inactivates residual white blood cells found in blood components, which may help to reduce transfusion reactions in patients. 

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Powerful, proven, and so much potential

The Mirasol PRT system is the only pathogen reduction technology system shown in a human clinical trial to reduce the transfusion-transmitted infection (TTI) of a disease, reducing TTI of malaria by 87%.¹

The right balance for better blood

We believe better blood safety should provide the right balance of efficacy and ease-of-use while maintaining the quality of blood components for patients who need them. Mirasol is a simple system that has the power to deliver better patient care, reducing the risks associated with the lifesaving gift of blood.

The Mirasol PRT system

You know better than anyone — these are challenging times. The Mirasol system allows you to meet the needs of your business by optimizing the balance of cost, efficacy, and safety of your blood products.²˒³

Safe

Mirasol is the only PRT system:

  • Shown to reduce incidence of a transfusion-transmitted disease in humans.¹
  • That uses riboflavin (vitamin B2), a non-toxic, non-mutagenic compound, to inactivate pathogens and white blood cells.¹˒⁴˒⁵˒⁶
Simple

The Mirasol process has fewer steps than other PRT methods, and the device can be used to treat platelets, plasma, and whole blood. This simplicity helps minimize the impact to operation.⁷˒⁸˒⁹

Effective

Mirasol technology is effective in protecting against a broad spectrum of emerging tested and untested pathogens, including bacteria, parasites, and enveloped and non-enveloped viruses. It also inactivates white blood cells, adding an extra layer of safety for patients. Blood products treated with the Mirasol PRT system maintain efficacy and help save patients’ lives.¹⁰⁻¹⁸

Affordable

Mirasol treatment can be used as an alternative to some safety procedures without introducing new risks for operators or patients.¹⁹⁻²¹ Treatment with the Mirasol PRT system can help reduce product discard rates for blood centers and reduce the overall cost of transfusion for hospitals.²˒³˒⁷˒⁸

Trusted partner

The Mirasol PRT system is a solution offered by Terumo Blood and Cell Technologies, a global leader in blood component technologies.

How it works

The right path to advancing blood safety: Safe, simple, effective

The Mirasol PRT system uses a combination of riboflavin (vitamin B2) — a non-toxic, non-mutagenic compound — and a specific spectrum of ultraviolet (UV) light to inactivate viruses, bacteria, parasites, and white blood cells that may be present in collected blood products.

The Mirasol PRT system consists of three main components:
  • A disposable kit — includes an illumination/storage bag and sterile riboflavin solution
  • The Mirasol Illuminator — provides UV light and agitation during the Mirasol treatment
  • Mirasol Manager software — integrates and manages data reporting and storage

During treatment, a blood product is mixed with the riboflavin solution and placed into the Illuminator, where it is exposed to UV light. There is no need to remove riboflavin or its photoproducts. After illumination, the treated products are ready for transfusion or placement into storage.

Mode of action

The Mirasol technology causes irreversible changes to the RNA and DNA of viruses, bacteria, parasites, and white blood cells, preventing them from replicating and causing disease.

Riboflavin + UV light = irreversible inactivation of pathogens and white blood cells

The process

Platelets, plasma, and whole blood in three simple steps

Step one: The product is transferred to the Mirasol illumination/storage bag.
Step two: Riboflavin solution is added and mixed with the product.
Step three: The mixture is then exposed to UV light.

Clinical experience with Mirasol-treated platelets

The Pathogen Reduction Evaluation & Predictive Analytical Rating Score (PREPAReS) clinical trial is the most comprehensive clinical trial to date demonstrating the non-inferiority of Mirasol-treated platelets. In addition, Terumo Blood and Cell Technologies hosted a webinar, “Clinical Experience With Mirasol-Treated Platelets,” presented by Dr. Jeffey McCullough, an international leader in research and practice of transfusion medicine and blood safety.  

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Featured resources

For operator's manuals and Instructions for Use, visit our eIFU website: Terumo.eifu.com. For more information, visit Help.TerumoBCT.com.

See how Mirasol can improve blood safety at your blood center.  

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Disclaimers and notes

The Mirasol PRT system is in conformance with the Medical Device Directive.

The Mirasol PRT system is not approved for sale in the U.S. It is available in select markets.

The Mirasol PRT system has received the CE mark for platelet, plasma, and whole blood applications.

  1. Allain JP, et al. Blood. 2015;126(23):770.
  2. Custer B, et al. Transfusion. 2010;50(11):2461-2473.
  3. Agapova M, et al. Transfus Med Hemother. 2015;42(3):158-165. 
  4. Mundt JM, et al. Photochem Photobiol. 2014;90(5):957-964.
  5. Reddy HL, et al. Transfus Med Rev. 2008;22(2):133-153.
  6. Goodrich RP, et al. Chapter 5: The Antiviral and Antibacterial Properties of Riboflavin and Light: Applications to Blood Safety and Transfusion Medicine. In: Flavins: Photochemistry and Photobiology. Royal Society of Chemistry; 2006.
  7. Jimenez-Marco T. The benefits of working with Mirasol PRT. Presented at: 4th Mirasol International Users Meeting; Estoril, Portugal; 2014.
  8. Bautista AM. Logistics and economical aspects of Mirasol implementation. Presented at: 5th Mirasol International Users Meeting; Palma de Mallorca, Spain; 2015.
  9. Jimenez-Marco T, et al. Transfus Med Hemother. 2014;41(3):172-175.
  10. Marschner S, Goodrich R. Transfus Med Hemother. 2011;38(1):8-18.
  11. Keil SD, et al. Transfusion. 2015;55(7):1736-1744.
  12. Keil SD, et al. J Vis Exp. 2015;102:52820.
  13. Yañez Izquierdo M, et al. Transfusion. 2009;49(suppl 3):84A.
  14. Yañez M, et al. Vox Sang. 2011;101(suppl 1):148.
  15. Coene GC, et al. Vox Sang. 2011;101(suppl 1):188-189.
  16. Mirasol Clinical Evaluation Study Group and RP Goodrich. Transfusion. 2010;50(11):2362-2375.
  17. Trakhtman P, et al. Transfusion. 2016;56(suppl. 1):S24-S28.
  18. Kaplan A, et al. Transfus Apher Sci. 2015;54(2):248-252.
  19. Fast LD, et al. Transfusion. 2011;51(7):1397-1404.
  20. Fast LD, et al. Transfusion. 2013;53(2):373-381.
  21. Goodrich RP, et al. Transfusion. 2009;49:1205-1216.

 

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