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Therapeutic Plasma Exchange for Nephrology

For nephrologists: Discover how cTPE can offer efficiency, flexibility, and dependability to help improve patient experience

FOR HEALTHCARE PROFESSIONALS


Centrifugal therapeutic plasma exchange (cTPE) provides nephrologists with a solution that adapts to their needs

The therapeutic plasma exchange (TPE) technology that you choose can make all the difference in finding a solution that adapts to your needs and improves patient experience. Discover centrifugal TPE (cTPE) on the Spectra Optia™ Apheresis System.

Plasma exchange technology can make a difference

Less time to finalize

It took the cTPE device one-third less time to finalize a procedure, compared to the membrane therapeutic plasma exchange (mTPE) device.1

Lower chance of clotting

No clotting was observed in the cTPE sessions  where the extracorporeal circuit was  anticoagulated with ACD-A.2

Shorter treatment time

cTPE treatment time was 10.5% shorter than mTPE treatment time 
(p < 0.05).3,4

How cTPE works

Spectra Optia uses differences in the specific gravity and sedimentation velocity of blood cells and plasma to separate specific blood components. 
 
With continuous flow centrifugation, blood is continuously added into the centrifuge; blood cells are separated from plasma, mixed with replacement fluid, and returned to the patient.

The graphic shown here is intended to be a high-level representation of an apheresis procedure and therefore does not cover all steps. For a detailed description, please contact Terumo Blood and Cell Technologies.

 

    
    
    

    What the Spectra Optia system offers

    With its cTPE technology, Spectra Optia provides clinicians with a solution that adapts to their needs and improves the patient experience. Schedule an on-site demonstration of the system to learn more.

    Spectra Optia simplifies the operator’s work and makes it easy to complete procedures.

    • The intuitive touch screen guides the operator through an eight-step TPE procedure
    • The operator can safely pause the procedure at any point without losing procedure information
    • The operator can access automated calculations of parameters, such as:
      • Total blood volume
      • Anticoagulant infusion rate
      • Plasma volume

    Spectra Optia helps enhance operator comfort and patient safety. It provides an efficient TPE procedure time while maintaining procedural safety limits, allowing operators to maximize the time with patients and improve the patient experience.

    Setup and prime = 11 minutes1,5

    Minimum time to exchange 1 L plasma = 10.7 minutes1,6

    Median time to exchange 1 L plasma = 30.6 minutes1,6

    Flow rates up to 142 mL/min can be used while maintaining procedure efficiency.7 For smaller patients, a flow rate of 5 mL/min or less can be used. This adapts to the operator’s needs and the patient’s condition.

    When tailoring a procedure for each patient, operators appreciate the flexibility of the multiple venous access options that can be used with the Spectra Optia system, including:

    • Peripheral venous access with single- or dual-needle options
    • Other venous access options, such as:
      • Central venous catheter
      • Arteriovenous (AV) fistula or AV graft
      • Implanted ports

    The reliability of Spectra Optia offers peace of mind for physicians and operators alike.

    • No clotting event resulting in premature ending of a TPE procedure or obligated use of an additional tubing set has ever been reported in peer-reviewed literature on Spectra Optia
    • The operator can depend on Spectra Optia to provide accurate anticoagulant management

    Featured resources

    For operator's manuals and Instructions for use, visit our eIFU website: Terumo.eifu.com. For more information, visit Help.TerumoBCT.com.

    Disclaimers and notes

    1. Kes P, et al. Transfusion. 2016;56(12):2065-3072.
    2. Puppe B, Kingdon EJ. Clin Kidney J. 2014;7(2):201-205.
    3. Hafer C, et al. Intl Urol and Nephrol. 2016;48(1):133-138.
    4. Peripheral access inlet flow rates were used on the cTPE device, but not on the mTPE system.
    5. Timing study based on internal laboratory time studies using highly trained operators. Time is approximate and results may vary depending on operator experience. Data on file.
    6. Data on file; encompasses data from more than 40,000 procedures.
    7. Procedures can be defined as being efficient in terms of the following:
    • Plasma removal efficiency (PRE)
    • Fluid balance
    • Anticoagulant management
    • Run targets
    • Pump flow rate accuracy
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